NowMi PRO: The Next-Generation Anti-Aging Facial Treatment

Aging is a part of life.  We all age.  But fortunately, anti-aging facial treatments can protect our facial skin and slow down the signs of aging.

The skin’s aging process occurs in two different ways – intrinsic and extrinsic aging. Intrinsic aging is related to the DNA we inherit from our parents, and it is inevitable and pre-determined.  As a result of intrinsic aging, the skin becomes thinner, less elastic and essentially dryer.  This is a direct result of a reduction in the overall production of collagen. This decrease, combined with gravitation, leads to the sagging of the skin.  The skin becomes dryer because with age the dermis is stripped of its ability to retain moisture. In addition, the aging process leads to a substantial reduction in the sweat glands and sebaceous glands which naturally provide moisture to the skin and help it look plump.  Extrinsic aging is associated with exposure to various toxins and environmental elements. The foremost and most detrimental element is the sun. UV sun rays cause an effect known as ‘photo-aging’ which results in the premature appearance of facial fine lines, wrinkles, age spots, freckles, enlarged pores, broken capillaries and rough, uneven skin tone.

The signs of aging that come with age

As we age, the changes listed below naturally occur:

  • Skin becomes coarser.
  • Skin becomes loose (the loss of the collagen and elastin causes the skin to hang loosely)
  • Skin becomes more translucent and thinner.
  • Skin becomes more brittle.

The NowMi Pro facial anti-aging Treatment

The NowMi Pro is an advanced, anti-aging facial treatment that consists of two parts.  The first is the NowMi Pro Daily sonic cleansing which cleanses and moisturizes the skin on a daily basis, and the second is the NowMi Pro Weekly sonic facial anti-aging treatment which provides a spa-quality anti-aging facial that slows down the formation of wrinkles and fine lines, reinvigorates the skin and protects it from damaging extrinsic factors such as UV rays, smoke and pollution.

The NowMi Pro package

NowMi Pro Treatment Benefits

  • A home-use treatment that includes a daily and a weekly facial anti-aging routine
  • A spa-quality anti-aging treatment adjusted to a home-use device, which delivers exceptional anti-aging and skin revitalization results:
    1. Reduces fine lines and textural imperfections.
    2. Hydrates skin and restores volume.
    3. Renews glow and revitalizes dull complexion.
  • Fast treatment performed in only 5 minutes
  • Treatment costs a fraction of the price compared to its spa based alternative.
  • Immediate and long-term results.
  • Compact, portable and lightweight.
  • Effective on all skin types.
  • Painless and pleasant.

The NowMi Pro Daily

Healthy facial skin starts with clean skin.  Sonic facial cleansing is much more effective than hand washing. With the NowMi Pro Daily, you can deeply cleanse the skin and get rid of all makeup, dirt, oil and the like.

The NowMi Pro sonic device is equipped with delicate silicone micro-fingers.   The NowMi cleansing formula is placed onto the micro-fingers and then massaged into the face.

The cleansing action is exponentially improved by sonic energy.  The NowMi Pro device issues 6,000 sonic pulsations per minute which help the cleansing gel penetrate and deeply cleanse all of the pores.  While the treatment is extremely effective, it is also very gentle on the skin and doesn’t cause irritation.

The cleansing gel does much more than just clean the skin.  It infuses it with vitamins B3, B5, E and Dead Sea minerals!  These essential vitamins and minerals rejuvinate and strengthen the skin as well as protect it from extrinsic factors.  Specifically:

  • Vitamin E: A powerful antioxidant that protects the skin from free radicals caused by UV exposure, pollution, smoke, unhealthy food and more.   Vitamin E is known for:
    1. Anti-aging: As a result of damaging extrinsic factors such as UV light and pollution, the skin creates free-radicals. These molecules damage the collagen and the skin cells.  As a result, wrinkles and brown spots appear.  Vitamin E plays a critical role in neutralizing the free radicals and thus preventing premature aging of the skin.
    2. Skin hydration: Vitamin E keeps the skin moisturized and supple, and it is also known to reduce inflammation.
    3. Scar reduction: Vitamin E neutralizes the free radicals which slow down the facial skin healing process and helps to prevent permanent scarring.
  • Vitamin B3: Vitamin B3 is effective on all skin types and has a wide variety of skin benefits. Specifically,
    1. Skin protection: Vitamin B3 is an antioxidant that protects the skin from infrared, UV and visible light. Vitamin B3 also protects the skin from heat, an important factor for those with hormonal related pigmentation since the heat can cause the overproduction of pigment.
    2. Hyper-pigmentation reduction: Vitamin B3 reduces hyper-pigmentation by reducing pigment production and its penetration into the skin. As a result, the skin has a more even complexion.  In addition, the vitamin has been shown to brighten the skin.
    3. Anti-aging: Niacinamide has been proven to reduce wrinkles, pigmented spots, yellowing and red blotchiness. It also stimulates the production of collagen and elastin which are responsible for the skin’s firmness and elasticity.
  • Vitamin B5: Also known as Pantothenic Acid, Vitamin B5 is deeply hydrating and helps the skin absorb moisture from the air.  It is also important in keeping the skin looking healthy and contributes to its softness and smoothness.   Its key advantages include:
    1. Natural hydrator: Vitamin B5 is a natural hydrator known as a humectant. Its function is to stabilize the skin’s barrier function.  As a result, the skin is able to retain greater quantities of water.
    2. Skin rejuvenation: The alcohol analog of Vitamin B5 is known as panthenol.  Panthenol has been proven to sooth and soften the skin and to slow down the signs of aging.   It also plumps and moisturizes the outer layer of the skin which helps it looks fuller and younger.
    3. Skin repair: Vitamin B5 is used to treat a variety of skin conditions- from minor skin irritation to major scar damage.  In addition, it has anti-inflammatory benefits and is used to reduce discomfort related to conditions such as eczema.
  • Dead Sea minerals: The Dead Sea is known as the richest source of healing minerals in the world.   The most prevalent minerals used to are:
    1. Zinc- regulates natural cell growth and regeneration. It enables cell renewal and stimulates the production of collagen and elastin. It is also an antioxidant that helps neutralize free radicals.  Zink also has anti-acne properties and is used as an anti-inflammatory agent.
    2. Calcium: Strengthens the skin’s cell membranes and cleanses the pores. It also soothes and relives the skin.
    3. Chloride- Corrects the balance of alkaline and acid in the skin’s cells which is critical for the metabolism of the cell.
    4. Sodium Chloride- hydrates and nourishes the skin’s cells and eliminates toxic waste which improves their permeability.

Another important action that the NowMi Pro Daily device performs that of a facial massage.  The sonic face brush massages the facial muscles which and boosts blood circulation. As a result, the body increases the production of collagen and elastin- key proteins that restore the skin’s elasticity and firmness.

The NowMi Pro sonic device is also highly hygienic since it is made of nonporous silicone which is resistant to bacteria buildup.  The device is also completely waterproof, so users can use it in the shower or bath.   Designed to keep up with today’s busy lifestyle, in a single charge, the device has enough energy to supply a month’s worth of treatments.

Watch the daily treatment 

NowMi Pro Weekly Treatment

With the NowMi Pro Weekly, you can enjoy a spa-quality anti-aging facial at home.   The treatment simultaneously performs 4 actions – sonic skin exfoliation, sonic nourishment, sonic oxygenation and sonic protection.

1.  Sonic exfoliation:  The exfoliation is performed using the NowMi vitamin C effervescent tablet.  The tablet is mixed together with the NowMi Lubricant gel and massaged into the face.  The tablet has a slightly coarse surface that removes the outermost layer of the skin.  The exfoliation is further enhanced by the sonic energy which emits 6,000 sonic pulsations per minute.  As a result of the exfoliation, the skin looks glowing and revitalized.  Best of all, the exfoliation opens up the pores and enables the active ingredients to best penetrate the skin.

The NowMi Pro device exfoliates the skin. The sonic energy enhances the results.

2.  Sonic nourishment:  The NowMi effervescent tablet contains virtually pure vitamin C, also known as ascorbic acid.  Ascorbic acid is highly sensitive and loses its potency if exposed to light or air.  For this reason, the NowMi effervescent tablet is vacuum-sealed until use, assuring the most effective form of vitamin C.
The NowMi lubricant gel is rich in vitamin E and Hyaluronic Acid.

The main benefits of these ingredients are:

  • Vitamin C: Vitamin C is hailed as the magic vitamin for skincare.  It has been clinically proven to revitalize the skin and help it repair itself.  Vitamin C is also an antioxidant that curbs the damaging effects of free-radicals which cause the skin to age prematurely.

Primary advantages of the vitamin include:

  1. Anti-aging effect: As we age, our skin has less and less collagen which causes it to sag and wrinkles to appear.  Vitamin C plays a vital role in helping the skin to produce new collagen.  With the new collagen, the aging process is slowed down and the skin looks plumper and more supple.
  2. Anti-inflammatory effect: Vitamin C reduces skin inflammation. This helps to prevent post-inflammatory hyper-pigmentation and age-related inflammatory skin conditions such as Rosacea.
  3. Anti-pigmentary effect: Vitamin C curbs the formation of melanin, the pigment that gives our skin its color.  It helps to repair pigmentation damage and provides the skin with a more even tone.  It also helps in lightening the skin.
  4. Skin protection: Vitamin C protects the skin from damaging UV rays.  The UV rays stimulate the formation of free radicals that harm the skin and cause premature aging, known as photoaging. Clinical studies have shown that vitamin C creates a photo-protective effect against photoaging  – it limits collagen disintegration and damage to the pigment,  helps to stabilize the collagen fibers, and produces new collagen.
  • Vitamin E:  Discussed above
  • Hyaluronic acid: Hyaluronic acid plays a critical role in skin hydration.  It is capable of holding 1,000 times its weight in water and helps tissues stay moist and lubricated.  Its key benefits are:
    1. Anti-aging:  When the skin is well hydrated, this slows down the formation of wrinkles and fine lines.
    2. Supple skin:  The hydration helps the skin to have a soft and supple appearance.
    3. Wound healing:  Hyaluronic acid accelerates the wound healing process by balancing inflammation levels and signaling the body to create more blood vessels in the treatment area.

The active ingredients are infused into the skin.  The infusion is improved by the sonic energy which helps them to penetrate deeper and faster into the skin.   Once the skin’s supply of vitamin C, E and Hyaluronic acid are restored, the skin starts to repair itself and turn back the signs of aging.

The NowMi Pro treatment nourishes the skin with vitamin C, E and hyaluronic acid.

  1. Sonic Oxygenation: The NowMi treatment is unique since it stimulates the body to “oxygenate itself from within”.  During treatment, a chemical reaction occurs when the NowMi effervescent tablet comes into contact with the lubricant gel. The reaction creates a C02 rich environment on the skin’s surface.  The body responds to this by sending 02 infused blood cells to the treatment area.  This natural oxygenation process helps the skin cells to best absorb the active ingredients.   Furthermore, the NowMi Pro device emits 6,000 sonic pulsations per minute which degas the C02  microbubbles, and as a result, the oxygenation effect is increased exponentially.

The NowMi Pro treatment oxygenates the skin from within

  1. Sonic Protection:  Vitamin C is the most common antioxidant in the skin. Unfortunately, with age, its levels dramatically reduce, and aged skin has about 70% fewer antioxidants than young skin. With the deciline in Vitamin C, the skin becomes more vulnerable to extrinsic factors such as UV rays, pollution and smoke.
    The NowMi Pro treatment restores the skin’s vitamin C supply which helps it to protect and heal itself from damaging extrinsic factors.The sonic energy plays an important role in the protection of the skin.  The NowMi Pro device emits 6,000 sonic pulsations per minute which exponentially increases the infusion of the vitamin C, ensuring that it reaches deep into the skin.

The NowMi Pro treatment protects the skin from harmful extrinsic factors

Watch the NowMi Oxygen Facial treatment

The benefits of vitamin C on facial skin

Our skin is the largest organ in the body and its primary function is to protect our internal organs from the hostile environment. It protects us from pathogens, UV radiation, mechanical impacts, pollution, dangerous chemicals and dehydration.

The two main layers of the skin are the epidermis and dermis. The external layer, the epidermis, is the cellular layer that protects our internal organs. The dermis is the internal layer of the facial skin which provides elasticity and strength, as well as nutrition to the epidermal layer. The dermis is mainly composed of collagen fibers and has a complex network of vascular, lymphatic and neurons.

Facial skin contains high concentrations of vitamin C. The highest concentration is in the epidermis -about 60 (mg/100 g Wet Weight) compared with 10 (mg/100 g Wet Weight) in the dermis.  Unfortunately with age, facial skin rapidly loses this essential and protecting nutrient. Clinical studies shown that aged skin loses 70% of ascorbic acid (vitamin C) concentrations compared with young skin. As the concentrations of vitamin C decrease, facial skin becomes more vulnerable to the external environment and starts to age. Regretfully, human beings are unable to synthesize vitamin C in their bodies and must rely on oral intake of ascorbic acid or topical application of vitamin C.

How does vitamin C help the skin?

Anti-aging benefits: The dermis provides elasticity and strength to the facial skin.  Its main structure is collagen fibers and clinical studies have shown that from the age of about 20 we lose about 1% of collagen fibers in the skin every year, primarily due to sun exposure. In simple words, without any treatment, at age of 35, we have already lost approximately 15% the collagen fibers in our facial skin. This results in thinner skin and the appearance of fine lines and wrinkles. Therefore, vitamin C is essential for the production of new collagen fibers and its decrease results in collagen degradation.

Anti-inflammatory benefits: Vitamin C is an anti-inflammatory nutrient that helps to counter age-related inflammatory skin conditions such as Rosacea.  It also promotes wound healing and prevents post-inflammatory hyperpigmentation.

Skin whitening benefits: Vitamin C decreases the formation of melanin.  It therefore aids in skin lightening, helps the skin maintain an even tone and repairs pigmentation damage.

Protects skin from sun damage: UV rays from the sun cause photodamage which decreases the production of collagen.  This results connective tissue disruptions, damage to blood vessels, and impairment of the wound healing process.  Vitamin C is a powerful anti-oxidant capable of neutralizing the free radicals caused by the UV rays.  In addition, ascorbic acid increases the collagen synthesis and cross-linking and helps the skin repair itself, therefore reversing the UV-induced photodamage.

The biologically active form of vitamin C is ascorbic acid. Unfortunately, ascorbic acid is a very unstable molecule, yet this is actually the condition that makes it a powerful anti-oxidant. When ascorbic acid degrades (as a result of exposure to light and oxygen) it loses its benefits to the facial skin, and its color turns from white to yellow-brown.

In order for your skin to benefit the most from vitamin C you need to use pure and un-degraded ascorbic acid.  If you are using a topical product like vitamin C serum or vit C cream, and its color is already yellow, it most likely contains a degraded form of vitamin C and is useless.

The NowMi Treatment:

Facial treatments typically involve multiple steps that cleanse, exfoliate and nourish the skin in order to provide a clearer, more rejuvenated, and well-hydrated complexion.  Oxygen facial treatments in particular are known for their skin revitalization and anti-aging attributes.

The NowMi facial treatment is the latest advancement in oxygen facial treatments. The treatment consists of 4 simultaneous actions – exfoliation of the outer layer of the skin, infusion of essential nutrients and oxygenation of the treatment area from within the skin for optimal absorption and efficacy of the infused nutrients. In addition to these three steps which are performed in most professional facial treatments, the NowMi treatment adds a critical fourth step of skin protection.  The protection is achieved by infusing the skin with pure vitamin C, vitamin E and hyaluronic acid.

The vitamin C in the NowMi treatment is in the form of ascorbic acid.  It comes in an effervescent tablet which is sealed by a protective sachet from light and humidity.  This ensures that the purest and most potent levels of ascorbic acid penetrate the skin.

How does the NowMi treatment work?

The NowMi treatment performs 4 skin actions simultaneously:

  1. Exfoliation – The exfoliation is performed using the vitamin C effervescent tablet.  The tablet has a slightly coarse surface which gently removes the most external layer of the skin.  The exfoliation deeply cleanses the skin and removes all dead skin cells, dirt and oil.  It also opens up the pores so that they optimally absorb the active ingredients.
  2. Nourishment – The interaction between the effervescent tablet and the gel creates micro CO2 bubbles which deliver vitamin C, vitamin E and hyaluronic acid into the skin and restore its depleted reserves. Research has shown that when taken orally, the absorption levels of vitamin C are very low, and only a fraction of the quantity taken is used by the body and active in the skin. Therefore, in order to effectively nourish the skin, the vitamin C is best applied topically.  The ascorbic acid contained in the NowMi tablet is of the highest level of purity. This makes the tablet incredibly effective since unlike any other product on the market, the vitamin C isn’t exposed to air and light, factors which dramatically degrade its quality. By adding vitamin C, the skin is nourished with effective anti-aging, anti-inflammatory and anti- pigmentary agents.  The vitamin E and Hyaluronic acid help the skin maintain its moisture and firmness, and the vitamin E further enhances the effectiveness of the vitamin C.
  3. Oxygenation – The interaction between the gel and tablet creates micro CO2 bubbles that penetrate the skin’s surface. In response to the increase in CO2 levels, a physiological response called the Bohr Effect is triggered, and the body sends oxygen rich blood to the target area.  This increases the capillary flow and the skin’s metabolism which results in the optimal absorption of the active ingredients and more rapid cell turnover.
  4. Protection – Vitamin C is the most prevalent antioxidant in the human skin and can be found in large concentrations in the dermal and epidermal skin layers.  Unfortunately, the body is unable to produce vitamin C and serious deficiencies can even lead to disease.

As we age, the concentration of the antioxidants, including vitamin C decreases, and aged skin is said to have 70% less antioxidant concentrations compared to younger skin.  As the concentrations decrease, the skin becomes more vulnerable to damaging extrinsic factors such as solar UV radiation, pollution and smoking.  These factors are known to cause ‘oxidative stress’ which rapidly accelerates damage caused to the skin. While the antioxidants shield against the oxidative stress, excessive exposure can overwhelm the defense mechanism and result in photoaging, immunosuppression and photocarcinogenesis.  Clinical studies have shown that vitamin C creates a photoprotective effect against photoaging.   The vitamin curbs collagen disintegration and pigment damage.  Most importantly, vitamin C helps to stabilize the collagen fibers and produces new collagen.

Active Ingredients used for Facial Skin Whitening

The ingredients used for facial skin whitening activate biological processes that are intended to reduce or eliminate the production of melanin.

There are several means of achieving this reduction:

  • Inhibit tyrosinase synthesis
  • Use complex copper that inhibits tyrosinase function
  • Eliminate oxidation reactions that lead to the formation of melanin
  • Slow down the transfer of melanosomes to keratinocytes
  • Act upstream on the hormone that stimulates melanogenesis (MSH)

Most of the depigmenting agents currently on the market decrease melanogenesis by inhibiting tyrosinase activity in the melanocytes as well as by inhibiting melanosome maturation using one of the mechanisms described in the blog ‘Facial Skin Whitening’.


In the past hydroquinone was the main active ingredient used in facial skin whitening treatments, and it was thought to be safe and effective for skin lightening. However, several clinical studies concluded that there may be side effects associated with the long-term use of hydroquinone- there were reports of possible carcinogenicity and a link to ochronosis. As a result, the FDA withdrew the 1982 TFM for OTC skin bleaching drug products containing hydroquinone.  Since the banning of hydroquinone from the OTC market, there has been a growing demand for an alternative natural, safe, and efficacious de-pigmenting treatment.

Ascorbic acid (vitamin C)

Vitamin C can be found in a few different forms, but ascorbic acid is the most biologically active and effective form.

Ascorbic acid is a key ingredient in many physiological functions in the human body.  It is a powerful antioxidant since it donates electrons and prevents oxidation by keeping iron and copper atoms in their reduced states.

The physiological functions of Ascorbic acid include the synthesis of:

  • Collagen
  • Carnitine
  • Neurotransmitters
  • Tyrosine

Collagen production is crucial for repairing damaged facial tissue.  Clinical studies have shown that the skin heals faster and scars less when it is infused with vitamin C. Thus, Ascorbic acid is used to stimulate collagen production which results in smoother and more supple skin.

Ascorbic acid whitens facial skin by inhibiting the production of tyrosinase, which reduces the production of melanin. It also protects the skin from harmful damage caused by sun exposure.  Excessive exposure to sunlight, especially UV rays, creates reactive oxygen species in the skin that provoke skin damage. Vitamin C significantly reduces the impact of these reactive oxygen species by donating electrons which neutralize them.

With so many facial skin benefits, it is not surprising that there is an abundance of topical products (creams, gels, serums) containing vitamin C on the market. The products claim to treat a wide variety of skin conditions- from facial skin whitening to fine line and wrinkle reduction . However, it is critical to know that when applied topically, the efficacy of ascorbic acid is very small and often non-existent.  This is due to the fact that vitamin C (C6H8O6) is a very unstable molecule which degrades once it is exposed to light, and as soon as it degrades, it loses all of the benefits described above.

It is easy to detect the degradation of the vitamin C since it turns a yellow-brown color upon degradation. Cosmetic products that claim to have vitamin C as an active ingredient, and which are colored yellow-brown, are misleading consumers since in actual fact the vitamin C in these products has lost its skin rejuvenation properties and is an inactive, degraded, vitamin C.

The structure of the skin is another factor which greatly reduces the effectiveness of cosmetics containing vitamin C. The upper layer of the skin, the stratum corneum, protects the deeper layers of the skin by rejecting materials that attempt to penetrate it. Vitamin C is a hydrophilic molecule which easily dissolves in water, while the stratum corneum is hydrophilic, meaning it is water resistant. Therefore, to effectively penetrate vitamin C into the skin, it is essential to first exfoliate the stratum corneum.

Kojic acid

For over 30 years, Kojic acid has been used as a facial skin whitening agent. Kojic acid, like hydroquinone, prevents the formation of dopachrome – an intermediate stage in the biosynthesis of melanin. Kojic acid is obtained by the fermentation of a strain of Aspergillus orizae.

Since hydroquinone and its esters have been banned in several countries, Kojic acid has been used to replace it. Kojic acid at 1% concentration has bleaching properties,  but when it is used, it immediately turns the cosmetic emulsion yellow and within four to six weeks it turns it brown.  Furthermore, its acidity is very weak since it is linked only to the presence of a hydroxyl function in the molecule. Additionally, it is unstable since it is very sensitive to heat (above 40°C) and oxidizes easily.  Therefore, it must be added into emulsions when they are cooled and needs to be combined with antioxidants such as ascorbic acid (vitamin C).

Although relatively safe and effective, recent studies have shown that it is responsible for skin irritation, sensitization and in rare cases where it has been frequently used, it has been related to contact dermatitis.

In Japan, the country where Kojic acid was first used for skin bleaching, the product isn’t banned, but the authorities have stated that they don’t want new formulations to include the acid.

Niacinamide or nicotinamide or vitamin B3

Another way to achieve skin lightening is to limit the transfer of pigment into the skin cells. Niacinamide (vitamin B3) and Soy are primary nutrients which affect the transfer of melanosome and thus pigmentation.

Niacinamide (nicotinamide) is an effective skin lightener, especially for skin conditions in which hyperpigmentation may occur on the face or other visible parts of the body. Niacinamide has been found to reduce hyperpigmentation in a pigmented reconstructed epidermal (PREP) model by inhibiting 35-68% of melanosome transfer from melanocytes to keratinocytes. It inhibits melanosome transfer without affecting tyrosinase activity, melanin production, melanocyte number or cell viability. The melanosome transfer is modulated by protease-activated receptor 2 activation (PAR-2) leading to disrupted keratinocyte phagocytosis. Most importantly, Niacinamide inhibits the transfer of melanosomes to keratinocytes without affecting the activity of tyrosinase.

Alpha-Hydroxy Acids

A very popular method for lightening the skin uses alpha hydroxyl acids (AHA).  AHA is a natural ingredient that effectively exfoliates the skin and also helps with hyperpigmentation by speeding up skin’s natural cell turnover – known as Skin Turnover Acceleration

L(+) lactic acid is part of the alpha hydroxyl acids (AHA) group. It is known to stimulate the desquamation process which increases the skin’s cell renewal rate. This not only results in smoother skin and the disappearance of fine lines, but also causes melanogenic suppression or skin whitening activity (as a result of the suppression of the formation of tyrosinase). The product needs to be formulated at lower pH levels to speed up the cell renewal.

The use of lactic acid and other lactates in skin lightening products has multiple benefits such as moisturization, increase of the skin’s ceramide level and skin lightening.

B&A of a woman after a facelift

Facial Skin Whitening

Woman wearing fur hat similingIntroduction

More than ever before, there is a huge emphasis in the beauty market on skin tone.  Customers the world over are seeking effective products that will even out their skin tone, and many individuals with darker skin are looking for skin whitening products.

The desire to use skin whitening products varies considerably between cultures. Hyperpigmentation is the most common and distressing condition afflicting people in Western countries.  These individuals often seek to eliminate localized hyperpigmentation as well as to lighten their skin tone in general.  In Asian countries, skin whitening products are mainly used to achieve a whiter and brighter facial skin tone.

The main purpose of facial skin whitening products is to lighten the skin as well as even out the skin tone.  It is also used to treat pigmentation disorders such as blemishes, pregnancy marks and age spots.

The active ingredients in the facial skin whitening creams work in two ways:

  • By absorbing the UV rays, thus preventing the sun damaging and darkening the facial skin.
  • By reducing the production of melanin, the pigment found in the skin which is responsible for skin color and darkening.

Facial Skin Pigmentation

Dermal melanin is produced by melanocytes, cells that are located at the bottom layer of the skin. The type and amount of melanin synthesized by the melanocyte and its distribution pattern in the epidermis determines the actual color of the facial skin.

Melanin comes in two forms: pheomelanin and eumelanin. These two forms are found in facial skin and hair. Eumelanin is the form which mostly determines the skin color due to its high concentrations (i.e. the higher the concentration of eumelanin, the darker the skin tone).

All skin types also have pheomelanin in the skin and hair. Pheomelanin is responsible for creating pink to red hues in the skin and is found in high concentrations in red hair as well as in lips, nipples, glans of the penis and vagina.

Some research has stated that pheomelanin may become carcinogenic if exposed to UV light.

Facial Skin Pigmentation Mechanism

Melanin in melanocytes form due to a series of oxidative reactions involving tyrosine and the enzyme tyrosinase.

Eumelanin is formed from the amino acid tyrosine, when it is acted upon by the enzyme tyrosinase, which itself is dependent on its co-enzyme copper. A succession of oxidation reactions leads to the formation of indole-5,6-quinone, and then the colored polymer. This synthesis takes place in the melanosomes, cellular organelles that extend from the melanocytes, which are transferred to keratinocytes that migrate from the basal layer of the epidermis to the stratum corneum.

Melanin forms through a series of oxidative reactions involving the amino acid tyrosine and the enzyme tyrosinase.

Tyrosinase catalyzes three different reactions in the biosynthetic pathway of melanin in melanocytes: the hydroxylation of tyrosine to l-DOPA and the oxidation of l-DOPA to dopaquinone; furthermore, in humans, dopaquinone is converted by a series of complex reactions to melanin.

The first step is the most critical because the remainder of the reaction sequence can proceed spontaneously at physiological pH. Here, tyrosinase converts tyrosine to dihydroxyphenylalanine (DOPA) and then to dopaquinone. Subsequently, dopaquinone is converted to dopachrome through auto-oxidation, and finally to dihydroxyindole or dihydroxyindole-2-carboxylic acid (DHICA) to form eumelanin (black-brown pigment). The latter reaction occurs in the presence of dopachrome tautomerase and DHICA oxidase. In the presence of cysteine or glutathione, dopaquinone is converted to cysteinyl DOPA or glutathione DOPA. Subsequently, pheomelanin, a yellow-red pigment, is formed.

There are several means of reducing or eliminating melanin formation:

  • Inhibit tyrosinase synthesis
  • Complex copper to inhibit tyrosinase function
  • Eliminate oxidation reactions that lead to the polymer formation
  • Slow down the transfer of melanosomes to keratinocytes
  • Act upstream on the hormone that stimulates melanogenesis

Most of the depigmenting agents presently on the market decrease melanogenesis by inhibiting tyrosinase activity in melanocytes as well as by inhibiting melanosome maturation by one or other of the mechanisms described.

In the next blog some of the most popular active ingredient for facial skin whitening will be presented.

NowMi PRO clinical results

What happens to your facial skin after you quit smoking?

Here is one more reason to quit smoking- it makes you look much older than you are.  Dr. Flora Levin, an oculoplastic surgeon specializing in cosmetic eyelid surgery and non-surgical facial skin rejuvenation, provides this succinct description: “The facial skin of a 40-year-old heavy smoker resembles that on a non-smoking 70-year-old. The facial skin is dry and coarse with deep facial wrinkles and furrows, a slack jawline, discoloration and an uneven tone. The eyelids are often baggy with creped facial skin. The neck is saggy with loose skin and the blood vessels are dilated and prominent. The term ‘smoker’s face’ is used to describe these facial skin characteristics, which are all caused by smoking.[1]

Why does this happen?  It happens because the tobacco smoke contains thousands of chemicals and carcinogens that cause serious damage (we won’t talk about cancer and heart disease now, just about damage to the facial skin).  Primarily, cigarette smoke is detrimental to blood circulation and just one cigarettes can limit blood flow for up to and hour and a half.  Therefore, the facial skin is starved of oxygen for long periods of time which results in the breakdown of collagen and elastin- proteins that are essential for firm and healthy facial skin.

The list goes on.  Since the blood flow is hindered, there is an increase in broken capillaries and veins which cause dark scarring on the face.  Also, the nicotine slows down the healing process so the skin is less able to repair itself from intrinsic and extrinsic damage.  Lastly, distinct furrows and wrinkles are formed from smoking- the act of sucking on the cigarette causes lines around your mouth and brows, and since the action is repeated, the lines become more pronounced.

Bottom line- smoking causes premature facial skin aging, slows down wound healing and increases the rate of infection.  Smokers often suffer from discoloration of the teeth and tongue, wrinkles and fine lines, bags under the eyes, slack in the jawline and dry, coarse skin.  And unfortunately, smokers experience higher rates of facial skin disorders such as: skin cancer, psoriasis, Hidradenitis suppurativa (chronic boils in the groin and armpits area), lupus and acne.

Okay. Enough with all the gloom and doom. This post is about your facial skin after you quit.  So here is the good news.  Our bodies are the most wondrous machines, and if you give your body a chance, it will do its best to reverse the damage.  So once you quit smoking your blood circulation will improve and your facial skin will begin to heal itself.  This means that it will start to produce more collagen and elastin which will restore your skin’s firmness and elasticity.  Also, once you quit smoking, the coloration of your facial skin will dramatically improve since the skin won’t be infused with chemicals that suppress it.

Regarding the wrinkles, they may not go away  at once, but they won’t get worse.  There are however many things you can do to reduce wrinkles and fine lines. First, you can start by infusing your skin with vitamin C and E which help the skin to revitalize itself.  The NowMi treatment is excellent in this respect since it oxygenate your facial skin restoring the needed oxygen to your face. It infuses the skin with 50% concentration of pure vitamin C, vitamin E and hyaluronic acid.  The ingredients help the facial skin regain its firmness and elasticity and reduce the appearance of wrinkles as proved by clinical study. Best of all it is a personal skin oxygenation device and the NowMi vitamin C oxygen facial treatment can be done anywhere and anytime. It takes only 5 minutes to restore your glow and revitalized facial skin.

NowMi Pro is now on sale with Special Offer: Buy now a NowMi Pro Kit from the inventor of OxyGeneo and receive Free of Charge a NowMi refill kit (valued at $99) that will give you 3 extra months vitamin C oxygen facial treatments at home.

There are also a wide range of minimally and invasive aesthetic treatments out there.  The technologies are constantly evolving, and the results are really impressive.  No matter what path you choose, the first step is to say goodbye to smoking and hello to a healthier you.

Recommended reading NowMi vitamin C oxygen facial

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Oxygen facials

So many celebrities swear by oxygen facials to help them keep their facial skin looking their best.  Madonna is one of the most famous proponents and is said to have an oxygen facial treatment before every concert. Jusin Timberlake, Miranda Kerr and Naomi Campbell have also made public that oxygen facials are part of their beauty routine.

So what is the deal behind oxygen facials?  The treatment was first launched by Intraceuticals, an Australian beauty product company in 2002.  Since then the treatment has been improved and upgraded and today it involves the delivery of pressurized oxygen at 90-95% concentration to the facial skin and the infusion of specialized serums.  The serums include skin revitalization agents such as hyaluronic acid (a natural ‘filler’ of the skin), select vitamins (primarily vitamins for skin such as A, C and E), anti-oxidants and peptides.  The oxygen is antibacterial and is used to optimize the delivery of the serums’ ingredients into the facial skin.  The treatment is completely painless and takes about 30 minutes.  After the treatment the facial skin feels more hydrated and plump and there is a decrease in fine lines and wrinkles.

One of the issues with Oxygen facials is that there is no scientific proof that the oxygen penetrates the skin and enhances the delivery of the serum. New York board certified dermatologist Dr. Kally Papantoniou says: “There may not be any scientific proof yet…but the treatment is harmless and those who’ve had oxygen facials all swear by them.”

The NowMi vitamin C oxygen facial treatment has taken the concept of skin oxygenation to the next level. Rather than externally oxygenating the skin, the NowMi vitamin C oxygen facial treatment stimulates the facial skin to oxygenate itself from within. During the facial treatment, the chemical reaction between the vitamin C effervescent tablet and the gel creates a CO2 rich environment. The body responds to this by sending oxygen rich blood cells to the facial treatment area. Once the area is rich in oxygen, the vitamin C, E and Hydraulic acid which are infused during the facial treatment, best penetrate the skin. As a result, the facial skin glow and looks and feels firmer and younger.

A wise man once said: “A picture is worth a 1,000 words”. So instead of telling you how good the NowMi treatments are, we will show you real results from customers.

NowMi PRO clinical results

Another major advantage of the NowMi facial treatment is price.  While oxygen facial treatments costs between $200-300 a pop, the NowMi facial treatment costs a fraction of the price and can be carried out in the comfort of your home.

Recommended reading: Vitamin C oxygen facial : Clinical evidence